Selective Reduction of Central Pulse Pressure Under Angiotensin Blockage in SHR: Role of the Fibronectin- 5 1 Integrin Complex | Zendy

Augustine Kakou | Zendy; Yvonnick Bézie | Zendy; Nathalie Mercier | Zendy; Huguette Louis | Zendy; Carlos Labat | Zendy; P. Challande | Zendy; P. Lacolley | Zendy; M. E. Safar | Zendy

Open Access

Selective Reduction of Central Pulse Pressure Under Angiotensin Blockage in SHR: Role of the Fibronectin- 5 1 Integrin Complex

Author(s) -

Augustine Kakou,

Yvonnick Bézie,

Nathalie Mercier,

Huguette Louis,

Carlos Labat,

P. Challande,

P. Lacolley,

M. E. Safar

Publication year - 2009

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2009.87

Subject(s) - medicine , pulse pressure , integrin , fibronectin , angiotensin ii , blood pressure , reduction (mathematics) , renin–angiotensin system , pulse (music) , endocrinology , microbiology and biotechnology , cardiology , receptor , extracellular matrix , biology , geometry , mathematics , engineering , detector , electrical engineering

Meta-analyses of antihypertensive therapy suggest that, independently of blood pressure (BP) level, stroke prevention is influenced mainly by calcium-entry blockers (CEB) and cardiac risk prevention by angiotensin-converting enzyme inhibitors (ACEIs). The possibility that central systolic and pulse pressure (PP) reduction differs between the two drug classes for the same mean BP (MBP) has never been explored. Our aim was to compare carotid PP at the same MBP obtained with the CEB, amlodipine, and the ACEI, trandolapril, in spontaneously hypertensive rats (SHR), and to evaluate the resulting changes of fibronectin (Fn) and its integrin alpha5beta1 receptor on central PP and arterial stiffness.

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