Effects of G994T in the Lp-PLA2 Gene on the Plasma Oxidized LDL Level and Carotid Intima-Media Thickness in Japanese: The Shimane Study | Zendy

Tao Wang | Zendy; Kenji Karino | Zendy; Masayuki Yamasaki | Zendy; Y. Zhang | Zendy; Junichi Masuda | Zendy; Seiji Yamaguchi | Zendy; K. Shiwaku | Zendy; Toru Nabika | Zendy

Open Access

Effects of G994T in the Lp-PLA2 Gene on the Plasma Oxidized LDL Level and Carotid Intima-Media Thickness in Japanese: The Shimane Study

Author(s) -

Tao Wang,

Kenji Karino,

Masayuki Yamasaki,

Y. Zhang,

Junichi Masuda,

Seiji Yamaguchi,

K. Shiwaku,

Toru Nabika

Publication year - 2009

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2009.70

Subject(s) - medicine , intima media thickness , cardiology , carotid arteries

A single-nucleotide polymorphism (SNP), G994T, in the lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) gene is known to have a potent influence on the activity of the enzyme. As this enzyme hydrolyzes oxidized low-density lipoprotein (oxLDL), which is an important player in atherogenesis, the present study evaluated effects of the G994T genotype on the oxLDL level as well as on intima media thickness (IMT) in vivo.

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