Insulin Increases D5 Dopamine Receptor Expression and Function in Renal Proximal Tubule Cells From Wistar-Kyoto Rats | Zendy

Jian Yang | Zendy; Zhihong Cui | Zendy; Dan He | Zendy; Hui Ren | Zendy; Yu Han | Zendy; Chaoqin Yu | Zendy; Chuhua Fu | Zendy; Zheng Wang | Zendy; Chun Yang | Zendy; Xin Wang | Zendy; Lin Zhou | Zendy; L. D. Asico | Zendy; V. A. M. Villar | Zendy; Ulrich Hopfer | Zendy; Mantian Mi | Zendy; Chunyu Zeng | Zendy; Pedro A. José | Zendy

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Insulin Increases D5 Dopamine Receptor Expression and Function in Renal Proximal Tubule Cells From Wistar-Kyoto Rats

Author(s) -

Jian Yang,

Zhihong Cui,

Dan He,

Hui Ren,

Yu Han,

Chaoqin Yu,

Chuhua Fu,

Zheng Wang,

Chun Yang,

Xin Wang,

Lin Zhou,

L. D. Asico,

V. A. M. Villar,

Ulrich Hopfer,

Mantian Mi,

Chunyu Zeng,

Pedro A. José

Publication year - 2009

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2009.69

Subject(s) - medicine , endocrinology , insulin receptor , receptor , insulin , wortmannin , receptor expression , fenoldopam , protein kinase c , insulin receptor substrate , biology , dopamine receptor , phosphatidylinositol , signal transduction , microbiology and biotechnology , insulin resistance

Ion transport in the renal proximal tubule (RPT) is regulated by numerous hormones and humoral factors, including insulin and dopamine. Previous studies show an interaction between insulin and the D(1) receptor. Because both D(1) and D(5) receptors belong to the D(1)-like receptor subfamily, it is possible that an interaction between insulin and the D(5) dopamine receptor exists in RPT cells from normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs).

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