Clinical and Functional Correlates of Platelet Cyclic GMP in Essential Hypertensives | Zendy

Carlo Sala | Zendy; Marta Rescaldani | Zendy; E. Santin | Zendy; G. Bolla | Zendy; Cesare Cuspidi | Zendy

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Clinical and Functional Correlates of Platelet Cyclic GMP in Essential Hypertensives

Author(s) -

Carlo Sala,

Marta Rescaldani,

E. Santin,

G. Bolla,

Cesare Cuspidi

Publication year - 2009

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2009.60

Subject(s) - medicine , platelet , endocrinology , cyclic guanosine monophosphate , ristocetin , platelet activation , aldosterone , epinephrine , plasma renin activity , atrial natriuretic peptide , mean platelet volume , prostacyclin , nitric oxide , blood pressure , renin–angiotensin system , von willebrand factor

Platelets play a central role in atherothrombosis, which is responsible of major cardiovascular complications in human hypertension. Nitric oxide (NO) inhibits platelet aggregation via the second messenger cyclic guanosine monophosphate (cGMP). In essential hypertensives (EHs), we examined the relationship between platelet cGMP and clinical, hemodynamic, humoral variables as well as the responses to aggregating agents.

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