A Study on Polymorphisms of Elastin Gene in Chinese Han Patients With Isolated Systolic Hypertension | Zendy

Liehua Deng | Zendy; Rong Huang | Zendy; Zhanyin Chen | Zendy; Lei Wu | Zendy; Dingli Xu | Zendy

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A Study on Polymorphisms of Elastin Gene in Chinese Han Patients With Isolated Systolic Hypertension

Author(s) -

Liehua Deng,

Rong Huang,

Zhanyin Chen,

Lei Wu,

Dingli Xu

Publication year - 2009

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2009.53

Subject(s) - medicine , pulse wave velocity , single nucleotide polymorphism , arterial stiffness , elastin , blood pressure , cardiology , snp , essential hypertension , allele frequency , genotype , allele , diastole , endocrinology , gastroenterology , pathology , gene , genetics , biology

Elastin (ELN) is mainly located in the internal elastic lamina of large arteries. Degradation of ELN is expected to induce large vessel stiffness, which could lead to elderly systolic hypertension. Recent studies have shown that polymorphism of ELN is associated with stiffness of elastic arteries and elevated blood pressure; however, there are no further studies on isolated systolic hypertension (ISH).

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