A Quantitative Trait Locus for SBP Maps Near KCNB1 and PTGIS in a Population Isolate | Zendy

Maja Barbalić | Zendy; Nina Smolej Narančić | Zendy; Tatjana ŠkarićJurić | Zendy; Marijana Peričić Salihović | Zendy; Irena Martinović Klarić | Zendy; Lovorka Barać Lauc | Zendy; Branka Janičijević | Zendy; Martin Farrall | Zendy; Igor Rudan | Zendy; Harry Campbell | Zendy; Alan F. Wright | Zendy; N D Hastie | Zendy; Pavao Rudan | Zendy

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A Quantitative Trait Locus for SBP Maps Near KCNB1 and PTGIS in a Population Isolate

Author(s) -

Maja Barbalić,

Nina Smolej Narančić,

Tatjana ŠkarićJurić,

Marijana Peričić Salihović,

Irena Martinović Klarić,

Lovorka Barać Lauc,

Branka Janičijević,

Martin Farrall,

Igor Rudan,

Harry Campbell,

Alan F. Wright,

N D Hastie,

Pavao Rudan

Publication year - 2009

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2009.46

Subject(s) - quantitative trait locus , genetics , single nucleotide polymorphism , population , candidate gene , locus (genetics) , genetic linkage , genome wide association study , genetic association , biology , medicine , gene , genotype , environmental health

Population isolates are characterized by simplified genetic background and as such present promising opportunities for studying complex diseases. We performed a genome-wide linkage analysis for systolic (SBP) and diastolic blood pressure (DBP) followed up by the association analysis in the Croatian isolated island of Vis, where a very high prevalence of hypertension was reported (75%).

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