Xylosyltransferase Gene Variants and Their Role in Essential Hypertension | Zendy

Claudia Pönighaus | Zendy; H. J. L. Speirs | Zendy; Brian J. Morris | Zendy; Joachim Kühn | Zendy; K Kleesiek | Zendy; C Götting | Zendy

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Xylosyltransferase Gene Variants and Their Role in Essential Hypertension

Author(s) -

Claudia Pönighaus,

H. J. L. Speirs,

Brian J. Morris,

Joachim Kühn,

K Kleesiek,

C Götting

Publication year - 2009

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2009.4

Subject(s) - essential hypertension , allele , genotype , genetics , locus (genetics) , blood pressure , genotyping , gene , medicine , candidate gene , endocrinology , biology

An accumulation of extracellular matrix molecules, such as proteoglycans, is observed in the vascular wall of hypertensive patients. Xylosyltransferases I and II (XT-I and XT-II), the chain-initiating enzymes in the biosynthesis of proteoglycans, catalyze the transfer of D-xylose from UDP-D-xylose to specific serine residues of the core protein. Because associations between XYLT polymorphisms and an altered blood pressure have been observed, genetic variations in the XYLT genes might predispose to essential hypertension. The localization of the XYLT2 gene on chromosome 17q increases its attractiveness as this region has been reported to be a potential candidate locus for essential hypertension.

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