Steroid Biosynthesis and Renal Excretion in Human Essential Hypertension: Association With Blood Pressure and Endogenous Ouabain | Zendy

Grazia Tripodi | Zendy; Lorena Citterio | Zendy; Tatiana Kouznetsova | Zendy; Chiara Lanzani | Zendy; Monica Florio | Zendy; Rossana Modica | Zendy; Elisabetta Messaggio | Zendy; John M. Hamlyn | Zendy; Laura Zagato | Zendy; Giuseppe Bianchi | Zendy; Jan A. Staessen | Zendy; Paolo Manunta | Zendy

Open Access

Steroid Biosynthesis and Renal Excretion in Human Essential Hypertension: Association With Blood Pressure and Endogenous Ouabain

Author(s) -

Grazia Tripodi,

Lorena Citterio,

Tatiana Kouznetsova,

Chiara Lanzani,

Monica Florio,

Rossana Modica,

Elisabetta Messaggio,

John M. Hamlyn,

Laura Zagato,

Giuseppe Bianchi,

Jan A. Staessen,

Paolo Manunta

Publication year - 2009

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2009.3

Subject(s) - medicine , blood pressure , endogeny , ouabain , endocrinology , excretion , essential hypertension , renal physiology , biosynthesis , kidney , sodium , biochemistry , enzyme , biology , chemistry , organic chemistry

Endogenous ouabain (EO) has been linked with long-term changes in sodium balance and cardiovascular structure and function. The biosynthesis of EO involves, cholesterol side-chain cleavage (CYP11A1), 3-beta-hydroxysteroid dehydrogenase (HSD3B) with sequential metabolism of pregnenolone and progesterone. Furthermore, the renal excretion of cardiac glycosides is mediated by the organic anion transporter (SLCO4C1) at the basolateral membrane and the P-glycoprotein (PGP) (encoded by MDR1) at the apical membrane of the nephron.

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