Restoration of Cerebral Vascular Relaxation in Renin Congenic Rats by Introgression of the Dahl R Renin Gene | Zendy

Ines Drenjančević | Zendy; Brent D. Weinberg | Zendy; Andrew S. Greene | Zendy; Julian H. Lombard | Zendy

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Restoration of Cerebral Vascular Relaxation in Renin Congenic Rats by Introgression of the Dahl R Renin Gene

Author(s) -

Ines Drenjančević,

Brent D. Weinberg,

Andrew S. Greene,

Julian H. Lombard

Publication year - 2009

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2009.236

Subject(s) - medicine , congenic , renin–angiotensin system , introgression , endocrinology , gene , blood pressure , genetics , biology , population , environmental health

This study determined whether transfer of the renin gene from the Dahl salt-resistant (Dahl R) strain into the Dahl salt-sensitive (SS) genetic background restores the relaxation of middle cerebral arteries (MCAs) to different vasodilator stimuli in S/renRR renin congenic (SS.SR-(D13N1 and Syt2)/Mcwi) (RGRR) rats maintained on low-salt (0.4% NaCl) diet.

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