Open AccessEarly Increase in Autoantibodies Against Human Oxidized Low-Density Lipoprotein in Hypertensive Patients After Blood Pressure Control
Author(s) -
Sérgio Augusto Bueno Brandão,
Maria Cristina de Oliveira Izar,
S. M. Fischer,
A. O. Santos,
Cristina M. Monteiro,
Rui Póvoa,
Tatiana Helfenstein,
Antônio Carlos Carvalho,
Ana Monteiro,
Eduardo Ramos,
Magnus Gidlund,
A. M. Figueiredo Neto,
Francisco Antônio Helfenstein Fonseca
Publication year - 2009
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1038/ajh.2009.214
Subject(s) - medicine , blood pressure , hydrochlorothiazide , endocrinology , ambulatory blood pressure , perindopril , low density lipoprotein , lipoprotein , thiobarbituric acid , cholesterol , lipid peroxidation , oxidative stress
Oxidized lipoproteins and antioxidized low-density lipoprotein (anti-oxLDL) antibodies (Abs) have been detected in plasma in response to blood pressure (BP) elevation, suggesting the participation of the adaptive immune system. Therefore, treatment of hypertension may act on the immune response by decreasing oxidation stimuli. However, this issue has not been addressed. Thus, we have here analyzed anti-oxLDL Abs in untreated (naive) hypertensive patients shortly after initiation of antihypertensive therapeutic regimens.
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