Attenuation of Angiotensin II-Induced Hypertension and Cardiac Hypertrophy in Transgenic Mice Overexpressing a Type 1 Receptor Mutant | Zendy

Shahzad Ahmad | Zendy; Francesca Cesana | Zendy; E. Lamperti | Zendy; Haralambos Gavras | Zendy; Jun Yu | Zendy

Open Access

Attenuation of Angiotensin II-Induced Hypertension and Cardiac Hypertrophy in Transgenic Mice Overexpressing a Type 1 Receptor Mutant

Author(s) -

Shahzad Ahmad,

Francesca Cesana,

E. Lamperti,

Haralambos Gavras,

Jun Yu

Publication year - 2009

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2009.181

Subject(s) - medicine , cardiac hypertrophy , angiotensin ii , endocrinology , transgene , genetically modified mouse , mutant , renin–angiotensin system , receptor , muscle hypertrophy , angiotensin ii receptor type 1 , blood pressure , gene , biology , biochemistry

The angiotensin II (AngII) type 1 receptor (AT1) regulates cardiovascular function by activating various signal pathways. The purpose of this study was to evaluate the effects of a mutant AT1 receptor on AngII-responding blood pressure and cardiac hypertrophy in conjunction with altered AngII activation of RhoA and Akt.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research