Oxidative Stress Impairs Vasorelaxation Induced by the Soluble Guanylyl Cyclase Activator BAY 41-2272 in Spontaneously Hypertensive Rats | Zendy

Fernanda Priviero | Zendy; Saiprasad M. Zemse | Zendy; Carlos Eduardo Garcez Teixeira | Zendy; R. Clinton Webb | Zendy

Open Access

Oxidative Stress Impairs Vasorelaxation Induced by the Soluble Guanylyl Cyclase Activator BAY 41-2272 in Spontaneously Hypertensive Rats

Author(s) -

Fernanda Priviero,

Saiprasad M. Zemse,

Carlos Eduardo Garcez Teixeira,

R. Clinton Webb

Publication year - 2009

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2009.18

Subject(s) - soluble guanylyl cyclase , oxidative stress , endocrinology , medicine , enos , superoxide dismutase , nitric oxide , nitric oxide synthase , apocynin , mesenteric arteries , nadph oxidase , guanylate cyclase , artery

BAY 41-2272 (5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidin-4-ylamine) relaxes mesenteric arteries (MA) in a synergistic fashion with nitric oxide (NO). We hypothesized that the relaxation to BAY 41-2272 is decreased in spontaneously hypertensive rats (SHR) because of the reduced NO bioavailability in this strain and that relaxation would be improved by inhibiting the oxidative stress. We aimed to evaluate the influence of oxidative stress in BAY 41-2272-induced vasorelaxation in isolated MA from SHR.

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