Effects of 17-Hydroxyprogesterone on Tumor Necrosis Factor- -Induced Hypertension During Pregnancy
Author(s) -
Sharon Keiser,
Edward Veillon,
Marc Parrish,
William A. Bennett,
Kathy Cockrell,
Lison Fournier,
Joey P. Granger,
James N. Martin,
Babbette LaMarca
Publication year - 2009
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1038/ajh.2009.149
Subject(s) - medicine , endocrinology , tumor necrosis factor alpha , preeclampsia , blood pressure , alpha (finance) , kidney , pregnancy , biology , construct validity , nursing , patient satisfaction , genetics
Inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) may be an important link between placental ischemia and hypertension in preeclampsia. We examined the effect of 17-hydroxyprogesterone caproate (17-OHP) on TNF-alpha-stimulated endothelin (ET) production and hypertension during pregnancy.
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