Open AccessMaternal Endothelial Progenitor Colony-Forming Units With Macrophage Characteristics Are Reduced in Preeclampsia
Author(s) -
Chien-Yu Lin,
Augustine Rajakumar,
Daniel A. Plymire,
Vivek Verma,
Nenad Marković,
Carl A. Hubel
Publication year - 2009
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1038/ajh.2009.101
Subject(s) - preeclampsia , medicine , soluble fms like tyrosine kinase 1 , progenitor cell , andrology , endocrinology , peripheral blood mononuclear cell , umbilical vein , umbilical cord , vasculogenesis , endothelium , immunology , fetus , placental growth factor , pregnancy , vascular endothelial growth factor , stem cell , biology , in vitro , biochemistry , genetics , vegf receptors
Endothelial progenitor cells (EPCs) provide paracrine support to the vascular endothelium and may also replace damaged or senescent endothelial cells. Low numbers of endothelial progenitor colony-forming units (CFU-ECs) in culture are a predictive biomarker of vascular disease. We hypothesized that the number of CFU-ECs derived from maternal blood are decreased in women with preeclampsia compared to normal pregnancy.
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