Cilostazol Activates AMP-activated Protein Kinase and Restores Endothelial Function in Diabetes | Zendy

Katsuhiko Suzuki | Zendy; Kohsuke Uchida | Zendy; Naohiko Nakanishi | Zendy; Yuki Hattori | Zendy

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Cilostazol Activates AMP-activated Protein Kinase and Restores Endothelial Function in Diabetes

Author(s) -

Katsuhiko Suzuki,

Kohsuke Uchida,

Naohiko Nakanishi,

Yuki Hattori

Publication year - 2008

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2008.6

Subject(s) - cilostazol , ampk , endothelial dysfunction , medicine , enos , endocrinology , endothelium , nitric oxide , amp activated protein kinase , protein kinase a , tetrahydrobiopterin , nitric oxide synthase , pharmacology , phosphorylation , biology , microbiology and biotechnology , aspirin

Endothelial dysfunction plays a key role in atherogenesis. We investigated whether AMP-activated protein kinase (AMPK) activity is a downstream mediator of the beneficial effects of cilostazol on vascular endothelial cells and whether cilostazol might reverse endothelial dysfunction in diabetic rats.

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