Association Between Fatty Acid Binding Protein 3 Gene Variants and Essential Hypertension in Humans | Zendy

Takehisa Ueno | Zendy; Masayoshi Soma | Zendy; Yasuharu Tabara | Zendy; Katsushi Tokunaga | Zendy; K. Tahira | Zendy; Noboru Fukuda | Zendy; Kouichi Matsumoto | Zendy; Tomohiro Nakayama | Zendy; T. Katsuya | Zendy; Takehide Ogihara | Zendy; Yoshio Makita | Zendy; Akira Hata | Zendy; Michiko Yamada | Zendy; Nobuhiro Takahashi | Zendy; Nobuhito Hirawa | Zendy; S Umemura | Zendy; T. Miki | Zendy

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Association Between Fatty Acid Binding Protein 3 Gene Variants and Essential Hypertension in Humans

Author(s) -

Takehisa Ueno,

Masayoshi Soma,

Yasuharu Tabara,

Katsushi Tokunaga,

K. Tahira,

Noboru Fukuda,

Kouichi Matsumoto,

Tomohiro Nakayama,

T. Katsuya,

Takehide Ogihara,

Yoshio Makita,

Akira Hata,

Michiko Yamada,

Nobuhiro Takahashi,

Nobuhito Hirawa,

S Umemura,

T. Miki

Publication year - 2008

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2008.40

Subject(s) - essential hypertension , single nucleotide polymorphism , genotype , allele , haplotype , genetics , candidate gene , quantitative trait locus , locus (genetics) , medicine , population , blood pressure , gene , endocrinology , biology , environmental health

We have earlier identified a quantitative trait locus (QTL) on rat chromosome 5 that appears to be primarily under the control of the sympathetic nervous system. Because sympathetic overactivity is related to both hypertension and insulin resistance, FABP3 is a candidate gene for the link between this QTL and blood pressure regulation. In this study, therefore, we explored the role of FABP3 genetic variations in essential hypertension (EH) in humans.

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