Effect of Erythropoietin on Blood Pressure and on the Vascular Endothelial ET-1/ETB Receptor System | Zendy

Marie-Ève Rodrigue | Zendy; Isabelle Brochu | Zendy; P. D' orleans-Juste | Zendy; R. Larivierea | Zendy; Marc Lebel | Zendy

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Effect of Erythropoietin on Blood Pressure and on the Vascular Endothelial ET-1/ETB Receptor System

Author(s) -

Marie-Ève Rodrigue,

Isabelle Brochu,

P. D' orleans-Juste,

R. Larivierea,

Marc Lebel

Publication year - 2008

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2008.37

Subject(s) - erythropoietin , medicine , endocrinology , blood pressure , hematocrit , endothelin 1 , endothelin receptor , receptor , immunohistochemistry

Recombinant human erythropoietin (rhEPO) increases blood pressure (BP) and the vascular production of endothelin-1 in renal failure rats. This study was designed to investigate the effect of rhEPO on BP and on the ET-1/ET(B)R system in rats with normal renal function. To further characterize the effect of rhEPO on the ET-1/ET(B)R system, we also studied heterozygous (+/-) ET(B)R knockout (KO) mice.

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