Association of SLC34A2 Variation and Sodium–Lithium Countertransport Activity in Humans and Baboons | Zendy

Xiaojing Zheng | Zendy; Candace M. Kammerer | Zendy; Laura A. Cox | Zendy; Alanna C. Morrison | Zendy; Stephen T. Turner | Zendy; Robert E. Ferrell | Zendy

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Association of SLC34A2 Variation and Sodium–Lithium Countertransport Activity in Humans and Baboons

Author(s) -

Xiaojing Zheng,

Candace M. Kammerer,

Laura A. Cox,

Alanna C. Morrison,

Stephen T. Turner,

Robert E. Ferrell

Publication year - 2009

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2008.355

Subject(s) - baboon , single nucleotide polymorphism , snp , genetics , haplotype , biology , allele , genetic association , chromosome , candidate gene , genotype , gene , endocrinology

Sodium-lithium countertransport (SLC) activity, an intermediate phenotype of essential hypertension, has been linked to a region of baboon chromosome 5, homologous to human chromosome 4p. Human SLC34A2, located at chromosome 4p15.1-p15.3, is a positional candidate gene for SLC. The specific aim of this study was to identify genetic variants of the SLC34A2 gene in both baboon and human, and to examine the relationship of these polymorphisms with SLC activity and blood pressure.

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