Cardioprotective Effects of Pitavastatin on Cardiac Performance and Remodeling in Failing Rat Hearts | Zendy

Naohiko Kobayashi | Zendy; Hiroshi Takeshima | Zendy; Hiroki Fukushima | Zendy; Wataru Koguchi | Zendy; Yasuhiro Mamada | Zendy; Hirokuni Hirata | Zendy; Y. Machida | Zendy; Motoo Shinoda | Zendy; Norihiro Suzuki | Zendy; Fumie Yokotsuka | Zendy; Kaoru Tabei | Zendy; H Matsuoka | Zendy

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Cardioprotective Effects of Pitavastatin on Cardiac Performance and Remodeling in Failing Rat Hearts

Author(s) -

Naohiko Kobayashi,

Hiroshi Takeshima,

Hiroki Fukushima,

Wataru Koguchi,

Yasuhiro Mamada,

Hirokuni Hirata,

Y. Machida,

Motoo Shinoda,

Norihiro Suzuki,

Fumie Yokotsuka,

Kaoru Tabei,

H Matsuoka

Publication year - 2008

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2008.333

Subject(s) - wortmannin , enos , pitavastatin , medicine , protein kinase b , pi3k/akt/mtor pathway , endocrinology , phosphorylation , pharmacology , nitric oxide synthase , signal transduction , nitric oxide , statin , microbiology and biotechnology , biology

Activation of phosphatidylinositol 3-kinase (PI3K)-Akt signaling by statins increases the activity of endothelial nitric oxide synthase (eNOS). We investigate whether statins (pitavastatin) improve cardiac function and remodeling via eNOS production associated with the PI3K-Akt signaling pathway, Rho-kinase (ROCK) pathway, and the development of oxidative stress in Dahl salt-sensitive (DS) hypertensive rats with heart failure (DSHF).

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