COMT Genotype Influences the Effect of Alcohol on Blood Pressure: Results From the COMBINE Study | Zendy

Sherry H. Stewart | Zendy; Gábor Oroszi | Zendy; Patrick K. Randall | Zendy; Raymond F. Anton | Zendy

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COMT Genotype Influences the Effect of Alcohol on Blood Pressure: Results From the COMBINE Study

Author(s) -

Sherry H. Stewart,

Gábor Oroszi,

Patrick K. Randall,

Raymond F. Anton

Publication year - 2008

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2008.321

Subject(s) - catechol o methyl transferase , medicine , valine , genotype , blood pressure , methionine , endocrinology , alcohol , enzyme , sympathetic nervous system , homocysteine , norepinephrine , gene , biochemistry , amino acid , dopamine , biology

Heavy drinking can cause chronic hypertension, possibly due to effects on the autonomic nervous system. Catechol- O-methyltransferase (COMT) inactivates catecholamines, and a G to A substitution in codon 108 in the soluble COMT mRNA (or codon 158 in the membrane-bound form) substitutes methionine for valine and alters enzyme activity.

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