Hypertension in Transgenic Mice With Brain-Selective Overexpression of the 2B-Adrenoceptor | Zendy

Ekaterina Kintsurashvili | Zendy; Sylvia Shenouda | Zendy; Deborah Ignacia D. Ona | Zendy; Livia Ona | Zendy; Shahzad Ahmad | Zendy; Katya Ravid | Zendy; Haralambos Gavras | Zendy

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Hypertension in Transgenic Mice With Brain-Selective Overexpression of the 2B-Adrenoceptor

Author(s) -

Ekaterina Kintsurashvili,

Sylvia Shenouda,

Deborah Ignacia D. Ona,

Livia Ona,

Shahzad Ahmad,

Katya Ravid,

Haralambos Gavras

Publication year - 2008

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2008.314

Subject(s) - medicine , genetically modified mouse , adrenergic , adrenergic receptor , sympathetic nervous system , transgene , receptor , central nervous system , endocrinology , neuroscience , blood pressure , gene , genetics , biology

Previous studies have shown that the presynaptic alpha(2B)-adrenoceptor subtype in the central nervous system has a sympathoexcitatory function and its activation leads to a hyperadrenergic hypertensive state. The purpose of this project was to develop a novel hyperadrenergic model, a transgenic (TG) mouse model with brain-selective overexpression of the alpha(2B)-adrenergic receptor (alpha(2B)-AR).

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