Deletion of the 8 Integrin Gene Does Not Protect Mice From Myocardial Fibrosis in DOCA Hypertension | Zendy

Andrea Hartner | Zendy; Nada Cordasic | Zendy; Wolfgang Rascher | Zendy; Karl F. Hilgers | Zendy

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Deletion of the 8 Integrin Gene Does Not Protect Mice From Myocardial Fibrosis in DOCA Hypertension

Author(s) -

Andrea Hartner,

Nada Cordasic,

Wolfgang Rascher,

Karl F. Hilgers

Publication year - 2008

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2008.309

Subject(s) - osteopontin , discoidin domain , integrin , fibronectin , medicine , fibrosis , myocardial fibrosis , immunohistochemistry , myofibroblast , endocrinology , extracellular matrix , receptor , biology , microbiology and biotechnology , receptor tyrosine kinase

In the heart, the alpha8 integrin chain is expressed in fibroblasts and vascular smooth-muscle cells but its functional role in the myocardium is unknown. Integrins can contribute to tissue fibrosis in several organs. We tested the hypothesis that alpha8 integrin-mediated cell-matrix interactions add to cardiac fibrotic alterations during hypertension.

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