Estrogen Deficiency-Induced Alterations of Vascular MMP-2, MT1-MMP, and TIMP-2 in Ovariectomized Rats | Zendy

K K Lam | Zendy; PeiYun Cheng | Zendy; Gene Hsiao | Zendy; ShihYao Chen | Zendy; HsinHsueh Shen | Zendy; MaoHsiung Yen | Zendy; YenMei Lee | Zendy

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Estrogen Deficiency-Induced Alterations of Vascular MMP-2, MT1-MMP, and TIMP-2 in Ovariectomized Rats

Author(s) -

K K Lam,

PeiYun Cheng,

Gene Hsiao,

ShihYao Chen,

HsinHsueh Shen,

MaoHsiung Yen,

YenMei Lee

Publication year - 2008

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2008.306

Subject(s) - matrix metalloproteinase , ovariectomized rat , medicine , estrogen , endocrinology , extracellular matrix , microbiology and biotechnology , biology

Matrix metalloproteinases (MMPs) activity may modulate hypertension-related accumulation of extracellular matrix (ECM) in arteries. We tested whether estrogen deficiency induces alterations of vascular collagen, MMP-2, membrane-type 1-MMP (MT1-MMP), or tissue inhibitor of metalloproteinases-2 (TIMP-2) expression in ovariectomized rats, which may be associated with postmenopausal hypertension.

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