Impact of a Long-Term Sildenafil Treatment on Pressor Response in Conscious Rats With Insulin Resistance and Hypertriglyceridemia | Zendy

Delphine BehrRoussel | Zendy; Alexandra Oudot | Zendy; Sandrine Compagnie | Zendy; Diane Gorny | Zendy; Olivier Le Coz | Zendy; Jacques Bernabé | Zendy; C. Wayman | Zendy; L Alexandre | Zendy; François Giuliano | Zendy

Open Access

Impact of a Long-Term Sildenafil Treatment on Pressor Response in Conscious Rats With Insulin Resistance and Hypertriglyceridemia

Author(s) -

Delphine BehrRoussel,

Alexandra Oudot,

Sandrine Compagnie,

Diane Gorny,

Olivier Le Coz,

Jacques Bernabé,

C. Wayman,

L Alexandre,

François Giuliano

Publication year - 2008

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2008.273

Subject(s) - medicine , endocrinology , insulin resistance , sildenafil , endothelial dysfunction , blood pressure , hypertriglyceridemia , insulin , triglyceride , cholesterol

Insulin resistance constitutes a risk factor for endothelial dysfunction and subsequent cardiovascular diseases including hypertension. Daily treatment with phosphodiesterase type 5 (PDE5) inhibitors has beneficial effects on endothelial function in men with increased cardiovascular risk. Endothelium-dependent vasomotor function is ultimately linked to blood pressure (BP) regulation. We postulated that sildenafil would ameliorate BP and biological markers of endothelial function in fructose-fed rats (FFRs).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research