Uricosuric Action of Losartan via the Inhibition of Urate Transporter 1 (URAT 1) in Hypertensive Patients | Zendy

Toshihiro Hamada | Zendy; Kimiyoshi Ichida | Zendy; Makoto Hosoyamada | Zendy; Einosuke Mizuta | Zendy; Kiyotaka Yanagihara | Zendy; Kazuhiko Sonoyama | Zendy; Shinobu Sugihara | Zendy; Osamu Igawa | Zendy; Tatsuo Hosoya | Zendy; Akira Ohtahara | Zendy; Chiaki Shigamasa | Zendy; Yasuo Yamamoto | Zendy; Haruaki Ninomiya | Zendy; Ichiro Hisatome | Zendy

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Uricosuric Action of Losartan via the Inhibition of Urate Transporter 1 (URAT 1) in Hypertensive Patients

Author(s) -

Toshihiro Hamada,

Kimiyoshi Ichida,

Makoto Hosoyamada,

Einosuke Mizuta,

Kiyotaka Yanagihara,

Kazuhiko Sonoyama,

Shinobu Sugihara,

Osamu Igawa,

Tatsuo Hosoya,

Akira Ohtahara,

Chiaki Shigamasa,

Yasuo Yamamoto,

Haruaki Ninomiya,

Ichiro Hisatome

Publication year - 2008

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2008.245

Subject(s) - medicine , uricosuric , losartan , pharmacology , endocrinology , transporter , uric acid , hyperuricemia , blood pressure , angiotensin ii , biochemistry , chemistry , gene

The angiotensin receptor blocker losartan inhibited urate transporter 1 (URAT1) according to in vitro experiments. However, it is still unknown whether the inhibitory effect of losartan on URAT1 contributes to its uricosuric action in humans.

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