A Human Fatty Acid Amide Hydrolase (FAAH) Functional Gene Variant Is Associated With Lower Blood Pressure in Young Males | Zendy

Riccardo Sarzani | Zendy; Marica Bordicchia | Zendy; Fabio Salvi | Zendy; Giovanna Cola | Zendy; Elena Franchi | Zendy; Ilaria Battistoni | Zendy; Lucia Mancinelli | Zendy; A Giovagnoli | Zendy; Paolo DessìFulgheri | Zendy; A Rappelli | Zendy

Open Access

A Human Fatty Acid Amide Hydrolase (FAAH) Functional Gene Variant Is Associated With Lower Blood Pressure in Young Males

Author(s) -

Riccardo Sarzani,

Marica Bordicchia,

Fabio Salvi,

Giovanna Cola,

Elena Franchi,

Ilaria Battistoni,

Lucia Mancinelli,

A Giovagnoli,

Paolo DessìFulgheri,

A Rappelli

Publication year - 2008

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2008.198

Subject(s) - fatty acid amide hydrolase , medicine , blood pressure , endocrinology , allele , endocannabinoid system , genotype , antagonist , genetics , receptor , cannabinoid receptor , gene , biology

Fatty acid amide hydrolase (FAAH) inhibitors, preventing endocannabinoid (EC) degradation, reduce blood pressure (BP) and heart rate in young male (YM) hypertensive rodents. The functional human FAAH 129T gene variant results in reduced protein level and enzymatic activity but its relationship with BP is unknown. This study investigates the relationship among FAAH P129T alleles and cardiovascular features in YMs at baseline and after 9-year follow-up, and in older male obese hypertensive (OH) patients, in whom the EC system (ECS) is overactive.

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