Improvement of Cardiac Diastolic Function by Long-term Centrally Mediated Sympathetic Inhibition in One-Kidney, One-Clip Hypertensive Rabbits | Zendy

Isabelle Signolet | Zendy; Pascal Bousquet | Zendy; Laurent Monassier | Zendy

Open Access

Improvement of Cardiac Diastolic Function by Long-term Centrally Mediated Sympathetic Inhibition in One-Kidney, One-Clip Hypertensive Rabbits

Author(s) -

Isabelle Signolet,

Pascal Bousquet,

Laurent Monassier

Publication year - 2007

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2007.9

Subject(s) - medicine , rilmenidine , cardiology , diastole , renovascular hypertension , blood pressure , left ventricular hypertrophy , isovolumic relaxation time , hemodynamics , heart failure , muscle hypertrophy , ejection fraction , end organ damage , diastolic function , receptor , agonist

Hypertension is associated with left ventricular hypertrophy (LVH) and diastolic dysfunction. The sympathetic nervous system (SNS) is strongly implicated in these alterations. The possible beneficial effect of a centrally mediated sympathetic inhibition on the diastolic function in severe hypertension has never been studied. We have evaluated the cardiac effects (remodeling, diastolic and systolic functions) of a long-term treatment with a centrally acting drug, rilmenidine, in a model of severe renovascular hypertension.

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