Inhibition of Nitric Oxide Synthetase at Mid-gestation in Rats is Associated With Increases in Arterial Pressure, Serum Tumor Necrosis Factor- , and Placental Apoptosis | Zendy

Kiyomi Tsukimori | Zendy; Hideo Komatsu | Zendy; Kotaro Fukushima | Zendy; Tsunehisa Kaku | Zendy; Hideki Nakano | Zendy; Norio Wake | Zendy

Open Access

Inhibition of Nitric Oxide Synthetase at Mid-gestation in Rats is Associated With Increases in Arterial Pressure, Serum Tumor Necrosis Factor- , and Placental Apoptosis

Author(s) -

Kiyomi Tsukimori,

Hideo Komatsu,

Kotaro Fukushima,

Tsunehisa Kaku,

Hideki Nakano,

Norio Wake

Publication year - 2008

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2007.80

Subject(s) - preeclampsia , medicine , placentation , gestation , blood pressure , endocrinology , trophoblast , placenta , nitric oxide , pregnancy , saline , mean arterial pressure , tumor necrosis factor alpha , nitric oxide synthase , andrology , fetus , biology , heart rate , genetics

Reduced uteroplacental perfusion and maternal cardiovascular dysfunction have been considered to be the main pathophysiological features of preeclampsia. In order to determine whether inhibition of nitric oxide synthetase (NOS) during the initial stage of placentation is associated with impaired placental development and maternal cardiovascular dysfunction, we studied the effect of N-nitro-arginine methyl ester (L-NAME), a NOS inhibitor, on morphological changes in the placenta, maternal blood pressure, and serum tumor necrosis factor-alpha (TNF-alpha) in pregnant rats during the initial stage of placentation.

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