Cardioprotective Effect of Benidipine on Cardiac Performance and Remodeling in Failing Rat Hearts | Zendy

Tomoyuki Ohno | Zendy; Norihiro Kobayashi | Zendy; Kenichi Yoshida | Zendy; Hiromichi Fukushima | Zendy; Hirofumi Matsuoka | Zendy

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Cardioprotective Effect of Benidipine on Cardiac Performance and Remodeling in Failing Rat Hearts

Author(s) -

Tomoyuki Ohno,

Norihiro Kobayashi,

Kenichi Yoshida,

Hiromichi Fukushima,

Hirofumi Matsuoka

Publication year - 2008

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2007.51

Subject(s) - hydralazine , medicine , enos , endocrinology , nitric oxide synthase , pharmacology , nitric oxide , blood pressure

We have known that endothelial nitric-oxide synthase (eNOS) and oxidative stress may play a key role in cardiac performance in failing rat hearts. However, the interactions between eNOS or oxidative stress and bradykinin (BK) under treatment of calcium channel blockers (CCBs) remain unknown. To elucidate the mechanism underlying the cardioprotective effect of long-acting dihydropyridine CCBs, we evaluated the effect of benidipine on the BK-eNOS and NAD(P)H oxidase pathway in Dahl salt-sensitive (DS) rats with heart failure.

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