Effects of an ARB on Endothelial Progenitor Cell Function and Cardiovascular Oxidation in Hypertension | Zendy

Liang Yu | Zendy; Noboru Fukuda | Zendy; EnHui Yao | Zendy; Takeshi Matsumoto | Zendy; Norihiro Kobayashi | Zendy; Ryo Suzuki | Zendy; Y. Tahira | Zendy; Takahiro Ueno | Zendy; Ken Matsumoto | Zendy

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Effects of an ARB on Endothelial Progenitor Cell Function and Cardiovascular Oxidation in Hypertension

Author(s) -

Liang Yu,

Noboru Fukuda,

EnHui Yao,

Takeshi Matsumoto,

Norihiro Kobayashi,

Ryo Suzuki,

Y. Tahira,

Takahiro Ueno,

Ken Matsumoto

Publication year - 2007

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2007.5

Subject(s) - candesartan , medicine , tbars , endocrinology , oxidative stress , angiotensin ii , nadph oxidase , endothelial progenitor cell , progenitor cell , nicotinamide adenine dinucleotide phosphate , pharmacology , endothelial dysfunction , blood pressure , oxidase test , lipid peroxidation , biology , biochemistry , stem cell , enzyme , genetics

Angiotensin II (Ang II) receptor blocker (ARB) has been reported to have protective effects on the cardiovascular system independent of blood pressure reduction. Endothelial progenitor cells (EPCs) play a significant role in neovascularization of ischemic tissue. The average lifespan of EPCs was recently reported to be shortened by oxidative stress and regulated by anti-oxidative mechanisms. It has been reported that EPCs are present in peripheral blood and have the ability to repair cardiovascular damage. We investigated the effects of an ARB, candesartan, on EPC function and cardiovascular oxidation in salt-loaded, stroke-prone, spontaneously hypertensive rats (SHR-SP) in vivo.

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