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Pulse Pressure Lowering Effect of Dual Blockade With Candesartan and Lisinopril vs. High-dose ACE Inhibition in Hypertensive Type 2 Diabetic Subjects: A CALM II Study Post-hoc Analysis
Author(s) -
Søren Tang Knudsen,
N.H. Andersen,
Steen Hvitfeldt Poulsen,
Hans Eiskjær,
Klavs Würgler Hansen,
Kjeld Helleberg,
P. L. Poulsen,
C. E. Mogensen
Publication year - 2008
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1038/ajh.2007.2
Subject(s) - lisinopril , candesartan , medicine , ambulatory blood pressure , blood pressure , post hoc analysis , blockade , ace inhibitor , type 2 diabetes , microalbuminuria , urology , cardiology , placebo , endocrinology , diabetes mellitus , angiotensin ii , angiotensin converting enzyme , receptor , alternative medicine , pathology
Elevated pulse pressure (PP) is strongly associated with micro- and macrovascular complications in type 2 diabetic patients. We examined the effect of 12 months of dual blockade with candesartan and lisinopril vs. high-dose lisinopril monotherapy on ambulatory PP in hypertensive type 2 diabetic patients from the CALM (Candesartan and Lisinopril Microalbuminuria Trial) II study.

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