Open AccessRegional Association-based Fine-mapping for Sodium-Lithium Countertransport on Chromosome 10
Author(s) -
Alanna C. Morrison,
Eric Boerwinkle,
S. T. Turner,
R E Ferrell
Publication year - 2007
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1038/ajh.2007.17
Subject(s) - single nucleotide polymorphism , linkage disequilibrium , genetics , genetic association , quantitative trait locus , snp , genetic linkage , association mapping , pedigree chart , biology , medicine , genotype , gene
Increased erythrocyte sodium-lithium countertransport (SLC) has been observed in patients with essential hypertension. Consistent evidence of genetic linkage was shown for SLC on chromosome 10, and a region of interest was localized between 26 and 56 Mb.
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