Ascorbic Acid Decreases the Binding Affinity of the AT1 Receptor for Angiotensin II
Author(s) -
Patrice Leclerc,
Christophe D. Proulx,
Guillaume Arguin,
Simon Bélanger,
Fernand Gobeil,
Emanuel Escher,
Richard Leduc,
G Guillemette
Publication year - 2007
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1038/ajh.2007.1
Subject(s) - ascorbic acid , angiotensin ii , receptor , endocrinology , medicine , angiotensin ii receptor type 1 , biochemistry , chemistry , food science
Ascorbic acid is an essential vitamin and a powerful antioxidant. Many studies have highlighted the benefits of ascorbic acid for chronic cardiovascular diseases such as hypertension in which angiotensin II (Ang II) plays an significant role. We therefore hypothesized that ascorbic acid could modify the pharmacological properties of the AT(1) receptor for Ang II.
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