Four deaths and a funeral: from caspases to alternative mechanisms | Zendy

Marcel Leist | Zendy; Marja Jäättelä | Zendy

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Four deaths and a funeral: from caspases to alternative mechanisms

Author(s) -

Marcel Leist,

Marja Jäättelä

Publication year - 2001

Publication title -

nature reviews molecular cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 37.461

H-Index - 431

eISSN - 1471-0080

pISSN - 1471-0072

DOI - 10.1038/35085008

Subject(s) - caspase , proteases , programmed cell death , apoptosis , biology , demise , microbiology and biotechnology , intrinsic apoptosis , genetics , enzyme , biochemistry , political science , law

A single family of proteases, the caspases, has long been considered the pivotal executioner of all programmed cell death. However, recent findings of evolutionarily conserved, caspase-independent controlled death mechanisms have opened new perspectives on the biology of cell demise, with particular implications for neurobiology, cancer research and immunological processes.

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