A novel potent vasoconstrictor peptide produced by vascular endothelial cells | Zendy

Masashi Yanagisawa | Zendy; Hiroki Kurihara | Zendy; Sadao Kimura | Zendy; Yoko Tomobe | Zendy; Mieko Kobayashi | Zendy; Youji Mitsui | Zendy; Yoshio Yazaki | Zendy; Katsutoshi Goto | Zendy; Tomoh Masaki | Zendy

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A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Author(s) -

Masashi Yanagisawa,

Hiroki Kurihara,

Sadao Kimura,

Yoko Tomobe,

Mieko Kobayashi,

Youji Mitsui,

Yoshio Yazaki,

Katsutoshi Goto,

Tomoh Masaki

Publication year - 1988

Publication title -

nature

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 15.993

H-Index - 1226

eISSN - 1476-4687

pISSN - 0028-0836

DOI - 10.1038/332411a0

Subject(s) - endothelin receptor , vasoconstrictor agents , vasoactive , endogeny , peptide , endothelins , endothelin 1 , endothelium , biology , microbiology and biotechnology , chemistry , vasoconstriction , endocrinology , biochemistry , receptor

An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors known. Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelin is an endogenous modulator of voltage-dependent ion channels. Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system.

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