APOE ε4 and cognitive function in early life: A meta-analysis. | Zendy

Andreas Ihle | Zendy; David Bunce | Zendy; Matthias Kliegel | Zendy

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APOE ε4 and cognitive function in early life: A meta-analysis.

Author(s) -

Andreas Ihle,

David Bunce,

Matthias Kliegel

Publication year - 2012

Publication title -

neuropsychology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.13

H-Index - 130

eISSN - 1931-1559

pISSN - 0894-4105

DOI - 10.1037/a0026769

Subject(s) - psychology , cognition , dementia , apolipoprotein e , association (psychology) , affect (linguistics) , effects of sleep deprivation on cognitive performance , developmental psychology , meta analysis , population , clinical psychology , disease , psychiatry , medicine , communication , environmental health , pathology , psychotherapist

It is well established that the Apolipoprotein E (APOE) ε4 allele is associated with cognitive impairment and Alzheimer's disease in old age. By contrast, several studies have demonstrated cognitive benefits in young ε4 carriers. It is therefore possible that the ε4 allele exhibits a pleiotropic association with cognition across the life span where ε4-related benefits in youth reverse to become risk factors for cognitive impairment and dementia in later life. To date, though, there has been no broad quantitative review of work assessing APOE-cognition associations in children, adolescents and young adults.

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