Open AccessAntifungal activity of histatin‐5 against non‐ albicans Candida species
Author(s) -
Nikawa H.,
Jin C.,
Fukushima H.,
Makihira S.,
Hamada T.
Publication year - 2001
Publication title -
oral microbiology and immunology
Language(s) - English
Resource type - Journals
eISSN - 1399-302X
pISSN - 0902-0055
DOI - 10.1034/j.1399-302x.2001.160409.x
Subject(s) - candida krusei , candida glabrata , candida parapsilosis , biology , candida tropicalis , candida albicans , microbiology and biotechnology , fungi imperfecti , mycosis , immunology
Fungicidal effects of histatin‐5 against 26 oral isolates belonging to 5 non‐albicans Candida species were examined. Fifty μM of histatin‐5 killed more than 95% of Candida tropicalis and Candida guilliermondii isolates and more than 90% of Candida parapsilosis and Candida krusei . However, Candida glabrata was less sensitive to the peptide (mean 62.9%). Our results, taken together, demonstrated that histatin‐5 possessed the fungicidal activity against Candida species other than C. glabrata .