Open AccessIncreased airway responsiveness to acetaldehyde in asthmatic subjects with alcohol‐induced bronchoconstriction
Author(s) -
Fujimura M,
Myou S,
Kamio Y,
Ishiura Y,
Iwasa K,
Hashimoto T,
Matsuda T
Publication year - 1999
Publication title -
european respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.021
H-Index - 241
eISSN - 1399-3003
pISSN - 0903-1936
DOI - 10.1034/j.1399-3003.1999.14a05.x
Subject(s) - bronchoconstriction , methacholine , acetaldehyde , alcohol , anesthesia , medicine , airway , asthma , ethanol , chemistry , endocrinology , lung , respiratory disease , biochemistry
Bronchial responsiveness to acetaldehyde, a main factor in alcohol‐induced bronchoconstriction, and methacholine were compared between 10 subjects with alcohol‐induced bronchoconstriction and 16 asthmatic subjects without alcohol sensitivity. In the alcohol‐sensitive group, the geometric mean (geometric sem ( gsem )) of the provocative concentration of methacholine (PC20,meth) and acetaldehyde (PC20,acet) causing a 20% fall in forced expiratory volume in one second were 0.947 mg·mL ‐1 ( gsem 0.139) and 21.0 mg·mL ‐1 ( gsem 0.112), respectively, which were not significantly different from those in the nonalcohol‐sensitive group, which were 0.634 mg·mL ‐1 ( gsem 0.115) and 31.7 mg·mL ‐1 ( gsem 0.077), respectively. The ratio of airway responsiveness to acetaldehyde relative to methacholine (log PC20,acet/PC20,meth) was 1.345±0.093 (mean± sem ) in the alcohol‐sensitive group, which was significantly different from the value of 1.699±0.059 in the nonalcohol‐sensitive group (p=0.0025). A significant correlation was observed between PC20,meth and PC20,acet in both the alcohol‐sensitive group (r=0.742, p=0.0115) and nonsensitive group (r=0.882, p<0.0001). In conclusion, the airways of asthmatic subjects with alcohol‐induced bronchoconstriction have a selective hyperresponsiveness to acetaldehyde.