Solventless Synthesis of N-Protected Amino Acids in a Ball Mill | Zendy

Laure Konnert | Zendy; Anne Gauliard | Zendy; Frédéric Lamaty | Zendy; Jean Martínez | Zendy; Evelina Colacino | Zendy

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Solventless Synthesis of N-Protected Amino Acids in a Ball Mill

Author(s) -

Laure Konnert,

Anne Gauliard,

Frédéric Lamaty,

Jean Martínez,

Evelina Colacino

Publication year - 2013

Publication title -

acs sustainable chemistry and engineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.878

H-Index - 109

ISSN - 2168-0485

DOI - 10.1021/sc4001115

Subject(s) - ball mill , ball (mathematics) , grinding , amino acid , environmentally friendly , chemistry , solvent , mill , carbamate , organic chemistry , materials science , chemical engineering , mathematics , engineering , metallurgy , geometry , biochemistry , ecology , biology

International audienceAn eco-friendly methodology for preparing carbamate N-protected α-amino acids is described using ball-milling technology. Some β-amino acids were also investigated in this study. This solvent-free methodology gave Boc-, Z-,and Fmoc-N-protected compounds in good to excellent yields with improved environmental impact compared to classical syntheses in solution. Different planetary ball mills were employed. The results are also discussed according to the different process parameters (grinding material, number of balls, rotation speed)

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