Perspective: A Program to Improve Protein Biomarker Discovery for Cancer | Zendy

Ruedi Aebersold | Zendy; Leigh Anderson | Zendy; Richard M. Caprioli | Zendy; Brian J. Druker | Zendy; Leland H. Hartwell | Zendy; Richard Smith | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Perspective: A Program to Improve Protein Biomarker Discovery for Cancer

Author(s) -

Ruedi Aebersold,

Leigh Anderson,

Richard M. Caprioli,

Brian J. Druker,

Leland H. Hartwell,

Richard Smith

Publication year - 2005

Publication title -

journal of proteome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.644

H-Index - 161

eISSN - 1535-3907

pISSN - 1535-3893

DOI - 10.1021/pr050027n

Subject(s) - biomarker discovery , biomarker , informatics , computational biology , cancer biomarkers , proteome , proteomics , identification (biology) , health informatics tools , cancer , bioinformatics , human proteome project , computer science , medicine , biology , biochemistry , botany , gene , electrical engineering , engineering

Biomarkers for cancer risk, early detection, prognosis, and therapeutic response promise to revolutionize cancer management. Protein biomarkers offer tremendous potential in this regard due to their great diversity and intimate involvement in physiology. An effective program to discover protein biomarkers using existing technology will require team science, an integrated informatics platform, identification and quantitation of candidate biomarkers in disease tissue, mouse models of disease, standardized reagents for analyzing candidate biomarkers in bodily fluids, and implementation of automation. Technology improvements for better fractionation of the proteome, selection of specific biomarkers from complex mixtures, and multiplexed assay of biomarkers would greatly enhance progress.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research