Burkholdines 1097 and 1229, Potent Antifungal Peptides from Burkholderia ambifaria 2.2N | Zendy

Kamilia A. Tawfik | Zendy; Peter W. Jeffs | Zendy; Brian L. Bray | Zendy; George R. Dubay | Zendy; Joseph O. Falkinham | Zendy; Mostafa K. Mesbah | Zendy; Diaa T. A. Youssef | Zendy; Sherief Khalifa | Zendy; Eric W. Schmidt | Zendy

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Burkholdines 1097 and 1229, Potent Antifungal Peptides from Burkholderia ambifaria 2.2N

Author(s) -

Kamilia A. Tawfik,

Peter W. Jeffs,

Brian L. Bray,

George R. Dubay,

Joseph O. Falkinham,

Mostafa K. Mesbah,

Diaa T. A. Youssef,

Sherief Khalifa,

Eric W. Schmidt

Publication year - 2010

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol9029269

Subject(s) - antifungal , chemistry , amphotericin b , microbiology and biotechnology , cyclic peptide , stereochemistry , peptide , amino acid , fungicide , biochemistry , biology , botany

Potent antifungal cyclic lipopeptides, burkholdines (Bk), were isolated from a culture of Burkholderia ambifaria 2.2N. Bk-1229 (1) and Bk-1097 (2) are octapeptides comprised of nonproteinogenic amino acids, including beta-hydroxytyrosine, beta-hydroxyasparagine, and a new fatty acyl amino acid. 1 and 2 are fungicidal against a panel of fungi with potencies 2-60-fold better than amphotericin B control.

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