Open AccessCopper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds
Author(s) -
Qiu Wang,
Stuart L. Schreiber
Publication year - 2009
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol902079g
Subject(s) - chemistry , nucleophile , copper , combinatorial chemistry , aromaticity , nitrogen , reaction conditions , molecule , organic chemistry , catalysis
A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C-H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs.
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