A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights | Zendy

Wei Gao | Zendy; Matthew L. Hillwig | Zendy; Luqi Huang | Zendy; Guanghong Cui | Zendy; Xueyong Wang | Zendy; JianQiang Kong | Zendy; Bin Yang | Zendy; Reuben J. Peters | Zendy

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A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights

Author(s) -

Wei Gao,

Matthew L. Hillwig,

Luqi Huang,

Guanghong Cui,

Xueyong Wang,

JianQiang Kong,

Bin Yang,

Reuben J. Peters

Publication year - 2009

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol902051v

Subject(s) - salvia miltiorrhiza , diterpene , chemistry , hydroxylation , abietane , biosynthesis , stereochemistry , functional genomics , computational biology , biochemistry , genomics , biology , traditional chinese medicine , enzyme , gene , medicine , alternative medicine , pathology , genome

Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis.

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