A Method for Parallel Solid-Phase Synthesis of Iodinated Analogues of the CB1Receptor Inverse Agonist Rimonabant | Zendy

Alan C. Spivey | Zendy; ChihChung Tseng | Zendy; Teyr C. Jones | Zendy; Andrew D. Kohler | Zendy; George J. Ellames | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A Method for Parallel Solid-Phase Synthesis of Iodinated Analogues of the CB₁Receptor Inverse Agonist Rimonabant

Author(s) -

Alan C. Spivey,

ChihChung Tseng,

Teyr C. Jones,

Andrew D. Kohler,

George J. Ellames

Publication year - 2009

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol902038y

Subject(s) - inverse agonist , chemistry , rimonabant , agonist , inverse , phase (matter) , combinatorial chemistry , solid phase synthesis , receptor , stereochemistry , computational chemistry , organic chemistry , biochemistry , cannabinoid receptor , mathematics , peptide , geometry

A method for the parallel solid-phase synthesis (SPS) of iodinated analogues of Sanofi-Aventis' type 1 cannabinoid (CB1) receptor inverse agonist rimonabant (acomplia) has been developed. The method allows the synthesis of a range of C3 amide/hydrazide derivatives from a resin-bound C3 ester precursor. The C-Ge linkage to the Hypogel-200 resin is stable to the diversification conditions but allows ipso-iododegermylative cleavage using NaI/NCS even for the products containing the oxidatively labile hydrazide moiety.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research