Open AccessBidirectional Metalation of Hydrobenzoin: Direct Access to New Chiral Ligands and Auxiliaries
Author(s) -
Inhee Cho,
Labros G. Meimetis,
Robert Britton
Publication year - 2009
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol900323u
Subject(s) - chemistry , metalation , combinatorial chemistry , organic chemistry
A bidirectional ortho metalation of the readily available chiral diol hydrobenzoin has been developed that provides direct access to new ortho-functionalized hydrobenzoin derivatives. This one-pot procedure should broaden the utility of hydrobenzoin as an auxiliary and ligand in asymmetric synthesis.
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