Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy | Zendy

Takuya Uchida | Zendy; Manuela Rodriquez | Zendy; Stuart L. Schreiber | Zendy

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Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy

Author(s) -

Takuya Uchida,

Manuela Rodriquez,

Stuart L. Schreiber

Publication year - 2009

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol900173t

Subject(s) - intramolecular force , chemistry , intermolecular force , stereoselectivity , pairing , molecule , diversification (marketing strategy) , small molecule , combinatorial chemistry , catalysis , computational chemistry , stereochemistry , organic chemistry , biochemistry , physics , superconductivity , quantum mechanics , marketing , business

Intermolecular couplings of simple building blocks using catalytic, stereoselective cross-Mannich reactions followed by intramolecular functional group-pairing reactions of easily accessed variants of the Mannich products are explored as a route to skeletally diverse small molecules. The synthetic pathway yields products having 12 different skeletons using only three steps and has the potential to enable substantial stereochemical diversification in the future.

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