Escherichia coli Glucuronylsynthase: An Engineered Enzyme for the Synthesis of β-Glucuronides | Zendy

Shane M. Wilkinson | Zendy; C.W. Liew | Zendy; Joel P. Mackay | Zendy; Hamzah Mohd. Salleh | Zendy; Stephen G. Withers | Zendy; Malcolm D. McLeod | Zendy

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Escherichia coli Glucuronylsynthase: An Engineered Enzyme for the Synthesis of β-Glucuronides

Author(s) -

Shane M. Wilkinson,

C.W. Liew,

Joel P. Mackay,

Hamzah Mohd. Salleh,

Stephen G. Withers,

Malcolm D. McLeod

Publication year - 2008

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol8002767

Subject(s) - chemistry , stereoselectivity , aryl , combinatorial chemistry , enzyme , stereochemistry , escherichia coli , organic chemistry , biochemistry , catalysis , alkyl , gene

The glycosynthase derived from E. coli beta-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of beta-glucuronides under mild conditions.

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