Open AccessFirst Total Synthesis and Structural Reassignment of (−)-Aplysiallene
Author(s) -
Jian Wang,
Brian L. Pagenkopf
Publication year - 2007
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol701797e
Subject(s) - chemistry , total synthesis , core (optical fiber) , key (lock) , combinatorial chemistry , stereochemistry , oxidative phosphorylation , biochemistry , ecology , materials science , composite material , biology
The first total synthesis of (-)-aplysiallene has been completed in 16 steps and features a key sequential Mukaiyama aerobic oxidative cyclization to prepare the fused bis-THF core. The original stereochemical assignment has been revised as shown.
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