Palladium-Catalyzed α-Arylation of Aryl Acetic Acid Derivatives via Dienolate Intermediates with Aryl Chlorides and Bromides | Zendy

ShengChun Sha | Zendy; Jiadi Zhang | Zendy; Patrick J. Walsh | Zendy

Open Access

Palladium-Catalyzed α-Arylation of Aryl Acetic Acid Derivatives via Dienolate Intermediates with Aryl Chlorides and Bromides

Author(s) -

ShengChun Sha,

Jiadi Zhang,

Patrick J. Walsh

Publication year - 2015

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol503545j

Subject(s) - aryl , chemistry , palladium , catalysis , acetic acid , halide , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl

To date, examples of α-arylation of carboxylic acids remain scarce. Using a deprotonative cross-coupling process (DCCP), a method for palladium-catalyzed γ-arylation of aryl acetic acids with aryl halides has been developed. This protocol is applicable to a wide range of aryl bromides and chlorides. A procedure for the palladium-catalyzed α-arylation of styryl acetic acids is also described.

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