Open AccessAccess to Large Cyclic Peptides by a One-Pot Two-Peptide Segment Ligation/Cyclization Process
Author(s) -
Emmanuelle Boll,
JeanPhilippe Ebran,
Hervé Drobecq,
Ouafâa ElMahdi,
Laurent Raibaut,
Nathalie Ollivier,
Oleg Melnyk
Publication year - 2014
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol503359w
Subject(s) - chemistry , ligation , native chemical ligation , chemical ligation , cysteine , residue (chemistry) , cyclic peptide , peptide , combinatorial chemistry , stereochemistry , biochemistry , medicine , enzyme
The use of the N-acetoacetyl protecting group for N-terminal cysteine residue enabled creation of an efficient and mild one-pot native chemical ligation/SEA ligation sequence giving access to large cyclic peptides.
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